Program 12th Rembrandt Symposium 19-11-2021 | ||
09:00-09:30 | Registration with coffee/tea | |
09.30-09.35 | PLENARY OPENING | |
09.35-11.00 | ORAL PRESENTATIONS PLENARY SESSION 1 Chairs: Dr. Vivian de Waard & Dr. Ilze Bot | |
9.35-10.00 | Prof. Dr. Connie Bezzina | Keynote lecture: Inherited Cardiac Disorders: From Monogenic to Polygenic |
10.00-10.10 | Maaike de Jong | Influenza and EBV specific CD8+ T-cells accumulate, but do not recognize antigen, in the atherosclerotic lesion |
10.10-10.20 | Maarten Graumans | Inflammation of perivascular adipose tissue as a predictor of the clinical course of COVID-19 |
10.20-10.30 | Karl Harber | Irg1 Derived Itaconate Controls Anti-Inflammatory Responses In Macrophages, Dampening Foam Cell Formation In Atherosclerotic Mice |
10.30-10.40 | Dieuwke Luijten | Incidence and impact of venous thromboembolism and major bleeding in patients with glioblastoma |
10.40-10.50 | Viviana Maraviglia | HiPSC-derived three-dimensional cardiac microtissues to study the contribution of cardiomyocytes and cardiac fibroblasts in Arrhythmogenic Cardiomyopathy pathogenesis |
10.50-11.00 | Arnout Mieremet | Altered Aortic Endothelial Cell Morphology in Marfan Syndrome Mice is Restored by Resveratrol |
11.00-11.30 | COFFEE BREAK | |
11.30-12.30 | POSTER BLITZ PARALLEL SESSION 1
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11.30-11.35 | Alwin de Jong | Co-stimulatory treatment enhances the protective role of CD4 and CD8 T cells in murine vein grafts. |
11.35-11.40 | Jill de Mol | B cell depletion skews cd4+ t cells towards a pro- inflammatory phenotype in aged atherosclerotic mice |
11.40-11.45 | Lucie Delfos | Mast cell-induced activation of immune cells in the atherosclerotic plaque |
Marie Depuydt | Identification of CD4+CD28null cells in advanced human atherosclerosis | |
11.50-11.55 | Geoffroy Goujon | Endothelial cells from genetic diverse mouse embryonic stem cells display varied responses to angiogenic cues. |
11.55-12.00 | Esmeralda Hemme | Bruton’s tyrosine kinase inhibition to suppress mast cell activation in atherosclerosis |
12.00-12.05 | Wietse In het Panhuis | Pharmacological treatment with designer cytokine and exercise mimetic IC7Fc reduces atherosclerosis development |
12.05-12.10 | Rosalie Kempkes | Reduced macrophage inflammatory responses following EZH2-inhibition |
12.10-12.15 | Veerle Kremer | Meg8 regulates tissue factor pathway inhibitor 2 (TFPI2) expression in the endothelium |
12.15-12.20 | Max Gronloh | Adhesion molecule heterogeneity in endothelial cells determines neutrophil transmigration hotspots and prevent vascular leakage |
12.20-12.25 | Sanne Lith | Nuclear Receptor Nur77 promotes resolution of inflammation in atherosclerosis |
12.25-12.30 | Vannessa Meyn | Trafficking of the VE-cadherin complex |
11.30-12.30 | POSTER BLITZ PARALLEL SESSION 2 Zoom link: https://us02web.zoom.us/j/7763807793
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11.30-11.35 | Cindy de Jong | Risk and outcomes of anticoagulation-associated abnormal menstrual bleeding in female patients with venous thromboembolism in their fertile age – the TEAM-VTE study |
11.35-11.40 | Wieke Grievink | Cardiovascular risk factors: the effects of aging and smoking on the immune system |
11.40-11.45 | Eva Janssen | Good anticoagulation is associated with low risk of adverse event and all-cause mortality in patients with continuous flow left ventricular assist devices. |
11.45-11.50 | Yvonne Jongejan | Identification of small interfering RNAs for allele-selective silencing of murine von Willebrand factor |
11.50-11.55 | Fleur Kaptein | Prevalence, treatment and prognosis of tumor thrombi in renal cell carcinoma |
11.55-12.00 | Sebastiaan Laan | Characterization of endothelial cell function in a patient with recurrent gastrointestinal bleeding using patient-derived endothelial colony forming cells |
12.00-12.05 | Milou Stals | Ruling out pulmonary embolism in patients with (suspected) COVID-19 – a prospective cohort studie |
12.05-12.10 | Viola strijbis | Human Prothrombin Variants with Modifications in the Active Site S4 Subpocket Demonstrate Resistance to Dabigatran |
12.10-12.15 | Jérémy Thalgott | Thresholds of Endoglin Expression in Endothelial Cells Explains Vascular Etiology in Hereditary Hemorrhagic Telangiectasia Type 1 |
12.15-12.20 | Kim Dzobo | Carotid endarterectomy plaques of patients with elevated levels of lipoprotein(a) demonstrate increased intraplaque angiogenesis |
12.20-12.25 | Ruben Methorst | Single nuclei RNA sequencing of the mouse superior cervical ganglia enables efficient tissue characterization at single cell resolution |
12.25-12.30 | Floris Tange | The Effect of Normalization on the Reliability of Quantitation of Tissue Perfusion Using Near Infrared Fluorescence with Indocyanine Green |
11.30-12.30 | POSTER BLITZ PARALLEL SESSION 3 Zoom link: https://uva-live.zoom.us/j/83467828475
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11.30-11.35 | Karolina Andrzejczyk | Identification of genetic variants in families with early onset of atrial fibrillation |
11.35-11.40 | Pranav Bhagirath | Cardiac magnetic resonance based predictors of ventricular arrhythmia recurrence following catheter ablation for ventricular tachycardia: initial experience |
11.40-11.45 | Sophia Chen | Differences in cardiac fibrosis and sympathetic innervation patterns within non-ischemic cardiomyopathy patients with anteroseptal versus inferolateral ventricular arrhythmia substrates |
11.45-11.50 | Jaël Copier | Bradycardia in a long QT type 2 family: coinciding KCNH2 and HCN4 variants |
11.50-11.55 | Michiel Blok | Effect of the Type I Interferon Signaling Pathway on Human Immortalized Atrial Myocyte Structural and Electrical Differentiation |
11.55-12.00 | Evita Marsman | Consortin: a novel modulator of cardiac conduction |
12.00-12.05 | Marieke Nederend | Atrioventricular-block necessitating ventricular pacing after tricuspid valve surgery in patients with a systemic right ventricle: long term follow-up. |
12.05-12.10 | Michele Nicastro | Variants in POPDC2 cause an autosomal-recessive cardiac disorder comprising sinus and atrioventricular node dysfunction, and hypertrophic cardiomyopathy |
12.10-12.15 | Kaylin Palm | Altered Auto-phosphorylation of Rare TNNI3K Variants in Families Presenting Supraventricular Arrhythmias, Conduction Disease, and Dilated Cardiomyopathy |
12.15-12.20 | Caroline Pham | Candidate-based and unbiased approaches to identify the downstream targets of TNNI3K |
12.20-12.25 | Dominic Zimmerman | Genetic Factors Predisposing to Sudden Cardiac Arrest |
12.25-12.30 | Pim van Gorp | Transcriptome analysis of conditionally immortalized atrial myocytes: identification of a novel atrium-enriched protein as a regulator of sarcomerogenesis |
12.30-13.30 | LUNCH | |
13.35-15.00 | ORAL PRESENTATIONS PLENARY SESSION 2 | |
13.35-14.00 | Prof. Dr. Johan Kuiper | Keynote lecture: Single cell research to elucidate novel immune pathways in atherosclerosis |
14.00-14.10 | Joost Offerhaus | Elucidating novel mechanistic pathways in Brugada syndrome |
14.10-14.20 | Koen Prange | Taming the macrophage: novel players in inflammatory activation |
14.20-14.30 | Friso Rijnberg | 4D flow MRI energetics in the Fontan circulation correlate with exercise capacity and MRI derived liver fibrosis |
14.30-14.40 | Gonzalo Sanches- Duffhues | GDF15 as a marker and mediator of vascular dysfunction in heart failure of non-ischemic origin |
14.40-14.50 | Thijs Sluiter | Short-term pre-operative Methionine Restriction protects from Vein Graft Disease via PPARα-dependent browning of perivascular adipose tissue |
14.50-15.00 | Robin van Eenige | Angiopoietin-like 4 dictates the day-night rhythm of metabolic brown adipose tissue activity |
15.00-15.30 | TEA BREAK | |
15.30-16.30 | POSTER BLITZ PARALLEL SESSION 4 Subject: Vascular Biology 2 | |
15.30-15.35 | Bam van Steen | Transendothelial migration induces differential migration dynamics of leukocytes in tissue matrix |
15.35-15.40 | Rimke Postel | Il-21r blockade reduces atherosclerosis development in ldlr- /- mice |
15.40-15.45 | Rudmer Postma | Endothelial Cell Painting Assay; utilizing morphological changes in endothelial cells to stratify patients in complex diseases. |
15.45-15.50 | Rianne Schoon | Endothelial junction remodeling in leukocyte transmigration |
15.50-15.55 | Virginia Smit | Age-associated B cells accumulate with age and promote atherosclerosis |
15.55-16.00 | Kim Dzobo | Elucidating the atherogenicity of Lp(a): an unbiased lipidomics approach |
16.00-16.05 | Daphne van den Homberg | Post-transcriptional modifications in vasoactive microRNAs during hypoxia; N-6-methyladenosine |
16.05-16.10 | Suzanne van Wouw | Multi-omic profiling of lxr activation identifies slpg as a sterol-inducible lysoplasmalogenase in macrophages |
16.10-16.15 | Robin Verwilligen | Inhibition of Interleukin-4 Induced Gene 1 (IL4i1) stimulates a pro-inflammatory immune environment |
16.15-16.20 | Tamar Woudenberg | Endothelial integrity in intracranial atherosclerosis; the role of tight junction proteins and pro-atherogenic microRNAs in lesion development. |
16.20-16.25 | Lichen Zhang | Cold-Inducible RNA-Binding Protein, but not its antisense lncRNA, is a direct negative regulator of angiogenesis in vitro and in vivo via regulation of 14q32 angiomiRs microRNA- 329-3p and microRNA-495-3p |
15.30-16.30 | POSTER BLITZ PARALLEL SESSION 5 Zoom link: https://us02web.zoom.us/j/7763807793
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15.30-15.35 | Anastasiya Burdzina | Unravelling Mitochondrial Dysfunction in Hypertrophic Cardiomyopathy |
15.35-15.40 | Jayron Habine | The protective role of FHL2-deficiency in glucose metabolism. |
15.40-15.45 | Cong Liu | Fibroblast growth factor 21 potently reduces atherosclerosis and NASH development |
15.45-15.50 | Amber Meurs | Genome-wide CRISPR-Cas9 screen to identify new proteins involved in intracellular cholesterol transport |
15.50-15.55 | Robin van Helden | HiPSC-derived cardiomyocytes from patients with infantile mitochondrial cardiomyopathy show diminished mitochondrial capacity and disrupted calcium homeostasis |
15.55-16.00 | Sanne Verberk | Macrophage ATP citrate lyase deficiency alters in vitro and in vivo inflammatory outcomes: A promising new target |
16.00-16.05 | Carmen Yap | The antibiotic doxycycline changes aortic smooth muscle cell metabolism and phenotype |
16.05-16.10 | Zhixiong Ying | Mirabegron activates thermogenic tissues to increase atherosclerosis only in absence of a functional hepatic ApoE- LDLR pathway for lipoprotein clearance |
16.10-16.15 | Novella Nicese | Sodium butyrate increases monolayer resistance and mitochondrial mass, while decreasing proliferation in glomerular endothelial cells |
16.15-16.20 | Katie Hanford | The duality of endothelial fatty acid oxidation in atherosclerosis |
16.20-16.25 | Merel Peletier | Using antibodies targeting oxidative stress epitopes to investigate and target ischemia reperfusion injury in a 2D and 3D heart on a chip model |
16.25-16.30 | Yiheng Zhang | PRMT4 inhibitor TP-064 impacts both inflammatory and metabolic processes without changing atherosclerosis susceptibility of male apolipoprotein E knockout mice |
15.30-16.30 | POSTER BLITZ PARALLEL SESSION 6 Zoom link: https://uva-live.zoom.us/j/83467828475
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15.30-15.35 | Paul Roos | Portal vein flow and pulsatility under different breath-hold conditions |
15.35-15.40 | Tamara Borsboom | Vascular Outflow Tract Development: A New Source of Smooth Muscle Cells in the Ascending Aorta |
15.40-15.45 | Marieke Nederend | Sacubitril/valsartan in the treatment of systemic right ventricular failure: follow-up. |
15.45-15.50 | Julius Heemelaar | Sailing in the mist: cardiotoxicity monitoring in adolescent and young adult osteosarcoma patients |
15.50-15.55 | Tom Streef | Single-cell RNA sequencing of human fetal epicardium reveals novel markers and regulators of EMT |
15.55-16.00 | Vincent Sier | Real-time Visualization of Vascular Remodeling by Ultra-High Frequency Ultrasound Imaging. |
16.00-16.05 | Diederick Verheijen | The potential role of IVUS in frequently encountered anomalous aortic origin of coronary arteries. |
16.05-16.10 | Fleur Zwanenburg | Fetal aortic stenosis: strong association between myocardial function on fetal ultrasound and post-mortem histology |
16.10-16.15 | Katerina Apelt | Functional ultrafast Doppler ultrasound imaging is a novel non-invasive and robust technique to detect and monitor early renal microvasculature defects in vivo |
16.15-16.20 | Paul Roos | Noninvasive MRI- and CFD-based left ventricular pressure- volume loops: Initial feasibility and Scan-Rescan reproducibility study |
16.20-16.25 | Yang Ge | Acute myocardial infarction induces dynamic neuronal remodelling in superior cervical ganglia |
16.25-16.30 | Joe Juffermans | Reproducibility of potential hemodynamic sources of aortic remodeling in patients with aneurysms of the ascending aorta and healthy volunteers |
16.30-17.00 | REMBRANDT PROJECT REPORTS PLENARY SESSION 3 Chairs: Prof. Patrick Rensen & Prof. Carlie de Vries | |
16.30-16.45 | Drs. Hayat Suleiman | The role of circular RNAs in phenotypic switching of vascular smooth muscle cells |
14.00-14.10 | Drs. Pablo Montañés- Agudo | The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes |
14.10-14.20 | AWARDS PLENARY SESSION 4 | |
17.00-17.05 17.05-17.10 17.10-17.15 17.15-17.20 | Best oral presentation Best poster presentation Poster Blitz session 1 and 2 Best poster presentation Poster Blitz session 3 and 4 Best poster presentation Poster Blitz session 5 and 6 | |
17.20-17.30 | HeArt competition - and the winner is .... | |
17.30-17.35 | REMBRANDT GRANT 2021 AWARD Presenter: Prof. Dr. Paul Quax | |
17.35-17.40 | CLOSING REMARKS Presenter: Prof. Dr. Paul Quax | |
17.40-18.30 | Drinks | |